Molecular Biology

Human genetic variation in APOE (Apolipoprotein E) and MAPT gene (Microtubule Associated Protein Tau) significantly influences risk for Alzheimer’s disease (AD) and tauopathies including frontotemporal dementia (FTD) and progressive supranuclear palsy. APOE alleles (ε2, ε3, ε4) primarily affect glial

We can now provide neurons and astrocytes with defined MAPT haplotypes, offering researchers access to cells selected by genetic background that is directly relevant to tau biology and neurodegenerative disease research.

What’s new?

• MAPT H1/H2 genotyping using SNP rs8070723
• H1c sub-haplotype identification

In CNS research, understanding disease mechanisms goes beyond tracking individual biomarkers—it requires insight into how entire biological pathways are regulated. From blood–brain barrier (BBB) integrity to glial activation and neuroinflammatory signaling, meaningful studies depend on high-resolution

APOE genotype–specific astrocyte biology has emerged as a central driver of Alzheimer’s disease and neurodegenerative risk. Recent studies demonstrate that the APOE4/4 genotype profoundly reshapes astrocyte function across multiple pathways, including lipid metabolism, neuroinflammatory signaling, and

We are excited to announce and launch two new products for Wnt/β-catenin signaling research: the TCF/LEF Dual Reporter Vector (TDRV, Catalog No. 9038) and the Luciferase Assay Kit (LAK, Catalog No. 9048).

The TDRV provides the reporter system, and the LAK provides the robust, accurate measurement,

Telomeric repeat–containing RNA (TERRA) plays a vital role in telomere biology, influencing telomerase activity, chromosome stability, and cellular aging. Abnormal TERRA expression has been linked to cancer, aging, and age-related diseases. But detecting TERRA has always been a challenge due to:

If your research depends on DNA, RNA, or protein lysates from human primary cells, you know how challenging and expensive it can be to isolate these materials yourself. That’s where ScienCell’s Human Cell Pellets come in, offering an opportunity to work with primary cells without the high cost and time

Save Time. Reduce Variability. Get Results. 

Working with primary cells is essential for biologically relevant data, but sourcing tissues, isolating cells, and extracting high-quality RNA, DNA, or protein can be time-consuming, expensive, and technically demanding.

Our line of cell-derived molecular

Pseudogenes are DNA segments similar to functional genes but with lost function. They were first described in 1977. Based on origin, they are classified as processed (e.g., human PTENP1), non-processed (e.g., human ARHGAP27P1), or unitary (e.g., human GULOP).

While many may not be functional or transcribed,

GeneQuery™ Disease Models qPCR Array Kits are powerful tools for understanding the molecular mechanisms underlying disease onset and progression. By measuring the activity levels of specific genes, researchers can gain crucial insights into disease pathways, identify potential biomarkers, and evaluate

What is DNA/RNA Isolation?

DNA/RNA isolation, also referred as nucleic acid purification, is the process of extracting and purifying DNA or RNA from biological samples like cells, tissues, and body fluids.

The purpose of DNA/RNA isolation is to obtain pure nucleic acid samples free from contaminants