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MAPT H1/H2 haplotyping H1c sub-haplotype stratification ApoE

We can now provide neurons and astrocytes with defined MAPT haplotypes, offering researchers access to cells selected by genetic background that is directly relevant to tau biology and neurodegenerative disease research.

What’s new?

  • MAPT H1/H2 genotyping using SNP rs8070723
  • H1c sub-haplotype identification via SNP rs242557
  • Multiple donors with different MAPT genotypes are available

Why this matters? 

MAPT genotypes are associated with differences in tau expression and behavior across donors. Cells carrying the H1c sub-haplotype tend to show higher tau expression or greater responsiveness under stress, while H1/H2 backgrounds are generally linked to lower tau-related activity. Selecting MAPT-typed neurons or astrocytes allows researchers to account for genetic variability, helping improve reproducibility and interpretation of tau-related experimental results. Having access to human primary neurons and astrocytes with known MAPT status allows for: 

  • More controlled experimental design
  • Reduced donor-to-donor variability
  • Improved interpretation of tau-related phenotypes and drug responses

 

Genotype selection helps control genetic variability and interpret experimental outcomes; observed effects may depend on assay conditions.

 

APOE status also available

We also offer APOE-typed neurons and astrocytes. MAPT typing is a new addition, designed to complement APOE stratification for researchers studying neuron–glia biology, tau pathology, and genetic risk.

 

Who may find this useful

  • Researchers studying tauopathies (e.g., AD, PSP, CBD, FTLD-tau)
  • Groups investigating neuron- or astrocyte-specific genetic effects
  • Drug discovery teams looking to test genotype-dependent responses
  • Labs aiming to improve reproducibility by controlling donor genetics

 

If you’d like to know which MAPT genotypes are currently available or want help selecting the right cells for your study, feel free to reach out via email, sales@sciencellonline.com

 

Important: When placing your order, please request MAPT typed donor cells and ask for the MAPT Certificate of Analysis (COA) to confirm genotype.