Pharmacogenomics

Why This Genotype Matters
 

TGFB1, Fibroblast Activation, and Extracellular Matrix Remodeling

Transforming growth factor beta 1 (TGF-β1), encoded by TGFB1, is a major regulator of fibroblast activity. When activated TGF-β1 binds to its receptors, it triggers signaling pathways, including SMAD2/3, that

Understanding the Impact of Genetic Variation on Endothelial Cell Function 

 
Endothelial dysfunction is a hallmark of cardiovascular disease and is closely associated with hypertension, diabetes, vascular aging, inflammation, and oxidative stress. Because endothelial nitric oxide synthase (eNOS), encoded