Human Pluripotent Stem Cell Derived-Motor Neurons

Motor neurons are specialized efferent neurons of the central nervous system that transmit signals from the brainstem and spinal cord to skeletal muscles, thereby controlling voluntary movement, muscle tone, and motor coordination. During development, motor neuron specification is regulated by defined morphogen gradients and transcriptional programs that establish ventral spinal cord identity and motor neuron fate. Human pluripotent stem cell-derived motor neurons provide a valuable in vitro model for studying motor neuron development, neuromuscular connectivity, electrophysiological function, and neurodegenerative diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy. Human Pluripotent Stem Cell-derived Motor Neurons (HPSC-MN) from ScienCell Research Laboratories provide a robust, reliable, and consistent off-the-shelf option for human motor neuron research. 

HPSC-MN are cryopreserved and delivered frozen. Each vial contains > 1 × 10⁶ cells in 1 ml volume. HPSC-MN are characterized by immunofluorescence with antibodies specific to pan neuronal marker beta tubulin III (TubbIII) and motor neuron markers MNX1. HPSC-MN are negative for mycoplasma, bacteria, yeast, and fungi. HPSC-MN can be cultured under the conditions provided by ScienCell Research Laboratories. HPSC-MN are not recommended for expansion since the cells do not proliferate in culture.