Human Pluripotent Stem Cells

Neurological diseases are among the most difficult human disorders to investigate. The brain is inaccessible during life, patient biopsies are rarely possible, and postmortem tissues generally represent advanced disease rather than the early cellular events that initiated it. Animal models remain essential,

Human pluripotent stem cells have fundamentally changed what is possible in biomedical research. Their capacity to self-renew indefinitely while retaining the potential to differentiate into any human cell type makes them a powerful platform for biological studies. Since Thomson et al. first described