Search results for: 'interleukins'

This kit profiles 88 key genes involved first steps of inflammation signaling. Inflammation occurs as a protective response against harmful stimuli and as a signal to initiate tissue repair. The initiation of inflammation involves immune cell migration to the insulted site by chemotaxis and immune cell activation by cytokines.

IL-11 receptor activation requires formation of a complex of two IL-11 molecules with two molecules of the ligand-binding IL-11Rα subunit and two molecules of the expressed cell signaling β subunit, gp130.

IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response.

The human IL-6 is a single non-glycosylated polypeptide chain containing 183 amino acids and it signals through a cell-surface type I cytokine receptor complex consisting of the ligand-binding IL-6Rα chain (CD126), and the signal- transducing component gp130 (also called CD130).

The human IL-3 reported to be a monomer. Specifically, human and murine IL-3 share low homology and it does not show activity on murine cells.

Recombinant Human Interleukin-1 beta (rhIL-1b) is a secreted pro-inflammatory cytokine belonging to the IL-1 family, produced primarily by activated monocytes, macrophages, and dendritic cells. The human IL-1b precursor (pro-IL-1b, 269 amino acids) is synthesized as an inactive cytoplasmic protein that undergoes proteolytic cleavage by caspase-1 (IL-1b–converting enzyme) to yield the mature 17 kDa cytokine.