Recombinant Human Interleukin-2
IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response.
IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. The receptor for IL-2 consists of three subunits (55 kDa IL-2Rα, 75 kDa IL-2Rβ, and 64 kDa common gamma chain γc/IL-2Rγ) that are present on the cell surface in varying preformed complexes. Mature human IL-2 shares 56 % and 66 % amino acid sequence identity with mouse and rat IL-2, respectively. Human and mouse IL-2 exhibit cross-species activity.
| Catalog No. | 101-02 |
|---|---|
| Country of Manufacture | United States |
| Product Code | rhIL-2 |
| Size/Quantity | 10 μg, 100 μg, or 1 mg |
| Product use | This product is for research use only. It is not approved for human or animal use, or for application in in vitro diagnostic procedures. |
| Storage | Upon receipt, store at -20°C after receiving. Upon reconstitution, store at 2-8 °C for up to one week. For maximal stability, aliquot and store at -20 °C. Avoid repeated freeze/ thaw cycles. |
| Shipping | Gel pack |
| Synonyms | IL2, T-cell Growth Factor, TCGF, Aldesleukin |
| AA Sequence | SAPTSSSTKKT QLQLEHLLLD LQMILNGINN YKNPKLTRML TFKFYMPKKA TELKHLQCLE EELKPLEEVL NLAQSKNFHL RPRDLISNIN VIVLELKGSE TTFMCEYADE TATIVEFLNR WITFCQSIIS TLT |
| Source | Escherichia coli |
| Molecular Weight | 15.4 kDa, a single non-glycosylated polypeptide chain containing 134 amino acids |
| Purity | > 95% |
| Physical Appearance | White lyophilized powder. |
| Formulation | Lyophilized from a 0.2µm filtered concentrated (1mg/ml) solution in PBS, pH 7.4. |
| Endotoxin | <0.1 ng/μg of protein (<1 EU/μg) |
| Reconstitution | Reconstitute in sterile distilled water containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |
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