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Recombinant Human NRG-1 (EGF-like domain) Beta 2
Recombinant Human NRG-1 (EGF-like domain) Beta 2 (rhNRG-1b2) β2 is an EGF family growth factor that activates ErbB receptor signaling and supports cell growth, differentiation, and tissue homeostasis. It is commonly used in cardiac, neural, stem cell, and regenerative medicine research.
Neuregulin-1 (NRG-1) is an EGF family growth factor involved in the regulation of cell growth, differentiation, and tissue homeostasis through activation of ErbB receptor signaling. The β2 isoform contains a distinct EGF-like domain sequence that binds ErbB3 and ErbB4 receptors, leading to receptor heterodimerization with ErbB2 and activation of multiple intracellular signaling cascades.
NRG-1 β2 contributes to cardiac and nervous system development by regulating ErbB receptor phosphorylation and downstream signaling. It supports cardiomyocyte survival and structural organization and has been utilized in studies investigating cardiac repair, neuronal function, stem cell differentiation, and regenerative medicine. The β2 isoform provides researchers with an additional NRG-1 variant for investigating isoform-specific ErbB signaling and biological responses.
| Catalog No. | 107-10b2 |
|---|---|
| Country of Manufacture | United States |
| Product Code | rhNRG-1b2 |
| Size/Quantity | 10ug, 50ug, 1mg |
| Product use | This product is for research use only. It is not approved for human or animal use, or for application in in vitro diagnostic procedures. |
| Storage | Upon receipt, store at -20°C after receiving. Upon reconstitution, store at 2-8°C for up to one week. For maximal stability, aliquot and store at -20°C. Avoid repeated freeze/ thaw cycles. |
| Shipping | Gel pack |
| Synonyms | NRG1-β2, HRGβ2, Heregulin β2, GGF2, ARIA, HGL, HRG, HRGA, MST131, NDF |
| AA Sequence | SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKAEELY Q |
| Source | E. coli |
| Molecular Weight | 7.0 kDa |
| Purity | > 95% |
| Physical Appearance | White lyophilized powder. |
| Formulation | Lyophilized from a 0.2µm filtered concentrated solution in 20 mM Tris-HCl pH7.5 and 300 mM NaCl with dextran as protectant. |
| Endotoxin | <0.1 ng/μg of protein (<1 EU/μg) |
| Reconstitution | Reconstitute in sterile distilled water or 1x PBS containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |
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