Recombinant Human Transforming Growth Factor-β3
Recombinant Human Transforming Growth Factor β3 consists of two identical 112-amino acid polypeptide chains connected by a single disulfide bond and has a molecular weight of 25.0 kDa.
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There are three mammalian isoforms of transforming growth factor-beta (TGF-β), namely TGF-β1, TGF-β2, and TGF-β3. These multifunctional cytokines signal through the same receptor and elicit similar biological responses. They play crucial roles in regulating cell proliferation, growth, differentiation, motility, and the synthesis and deposition of the extracellular matrix. These cytokines are secreted in precursor form consisting of a bioactive C-terminal domain attached to an N-terminal domain known as latency associated protein (LAP). Cleavage of LAP results in the mature protein, which functions as a disulfide-linked homodimer. As with all members of the family, TGF-β3 is highly conserved across species, with mouse and human TGF-β3 demonstrating 100% sequence homology and cross-species activity. Recombinant Human TGF-β3 consists of two identical 112-amino acid polypeptide chains connected by a single disulfide bond and has a molecular weight of 25.0 kDa.
| Catalog No. | 105-53 |
|---|---|
| Country of Manufacture | United States |
| Product Code | rhTGFb3 |
| Size/Quantity | 10ug, 50ug, 500ug |
| Product use | This product is for research use only. It is not approved for human or animal use, or for application in in vitro diagnostic procedures. |
| Storage | Upon receipt, store at -20°C after receiving. Upon reconstitution, store at 2-8°C for up to one week. For maximal stability, aliquot and store at -20°C. Avoid repeated freeze/ thaw cycles. |
| Shipping | Gel ice. |
| Synonyms | Transforming Growth Factor-β3, TGFB3, Beta 3, ARVD1, RNHF |
| AA Sequence | ALDTNYCFRN LEENCCVRPL YIDFRQDLGW KWVHEPKGYY ANFCSGPCPY LRSADTTHST VLGLYNTLNP EASASPCCVP QDLEPLTILY YVGRTPKVEQ LSNMVVKSCK CS |
| Source | mammalian cell |
| Molecular Weight | 25.0 kDa, a disulfide bond linked non-glycosylated polypeptide chains containing two 112 amino acids |
| Purity | > 95% |
| Physical Appearance | Light yellow to white powder |
| Formulation | Lyophilized from a 0.2µm filtered solution in 50 mM Glycine, 50 mM NaCl, pH 2.50. |
| Endotoxin | <0.1 ng/μg of protein (<1 EU/μg) |
| Reconstitution | Reconstitute in sterile distilled water or 0.1 M HCl containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |
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