Recombinant Human Neurotrophin-4
This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures.
Neurotrophin-4 (NT-4) is a member of the nerve growth factor (NGF) family of neuronal and epithelial growth factors. Like other neurotrophins, NT-4 contains six conserved cysteine residues that form three disulfide bonds essential for its structural stability. Human NT-4 shares 48–52% amino acid sequence identity with human β-NGF, BDNF, and NT-3, and exhibits high sequence conservation with rodent homologs, sharing 91% and 95% identity with mouse and rat NT-4/5, respectively. The mature NT-4 protein is secreted as a homodimer and can also form heterodimers with BDNF or NT-3. NT-4 binds to the TrkB receptor, inducing receptor dimerization and downstream signaling activation. Through TrkB signaling, NT-4 supports the development and survival of specific populations of peripheral and central nervous system neurons. NT-4-mediated TrkB activation enhances NMDA receptor activity and increases neuronal sensitivity to excitotoxic cell death. In addition to its neuronal functions, NT-4 promotes keratinocyte proliferation and accelerates hair follicle regression during the follicular cycle. NT-4 is also secreted by activated T cells and granulocytes at sites of inflammation, where it contributes to tissue regeneration.
| Catalog No. | 107-04 |
|---|---|
| Country of Manufacture | China |
| Product Code | rhNT-4 |
| Size/Quantity | 2ug, 10ug, or 100ug |
| Product use | This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures. |
| Storage | Upon receipt, store at -20°C after receiving. Upon reconstitution, store at 2-8°C for up to one week. For maximal stability, aliquot and store at -20°C. Avoid repeated freeze/ thaw cycles. |
| Shipping | Gel pack |
| Synonyms | NT-5, GLC10, GLC1O, NT-4/5 |
| AA Sequence | GVSETAPASR RGELAVCDAV SGWVTDRRTA VDLRGREVEV LGEVPAAGGS PLRQYFFETR CKADNAEEGG PGAGGGGCRG VDRRHWVSEC KAKQSYVRAL TADAQGRVGW RWIRIDTACV CTLLSRTGRA |
| Source | E. coli |
| Molecular Weight | 13.9 kDa |
| Purity | > 95% |
| Physical Appearance | White lyophilized powder. |
| Formulation | Lyophilized from a 0.2μm filtered concentrated solution in 20 mM Tris-HCl pH7.5 and 300 mM NaCl with dextran as protectant. |
| Endotoxin | <0.1 ng/μg of protein (<1 EU/μg) |
| Reconstitution | Reconstitute in sterile distilled water or 1x PBS containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |
No Publication available at this time.
