Human Seminal Vesicle Microvascular Endothelial Cells

The seminal vesicles (SV) are a pair of tubular glands located near the prostate and are essential to the urinary system. They function under androgen control to produce and secrete fluid into the ejaculatory duct. The SV consists of three layers: the inner basal mucosal layer composed of simple cuboidal and pseudo-stratified columnar epithelial cells, the middle muscular layer formed by smooth muscle cells, and the outer layer made up of dense connective tissue. Various pathological conditions can arise in the SV, including congenital SV cysts, seminal vesculitis, and primary and secondary neoplasms. Additionally, SV invasion is often used as a prognostic marker in prostate cancer. SV endothelial cells offer unique opportunities to study many features of the SV.

HSVMEC from ScienCell Research Laboratories are isolated from the human seminal vesicle. HSVMEC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10⁵ cells in 1 ml volume. HSVMEC are characterized by immunofluorescence with antibodies specific to vWF/Factor VIII and/or CD31 (PECAM1). HSVMEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HSVMEC are guaranteed to further expand for 10 population doublings under the conditions provided by ScienCell Research Laboratories

Recommended Medium

It is recommended to use Endothelial Cell Medium (ECM, Cat. #1001) for the culturing of HSVMEC in vitro.