Recombinant Human IGF-BP3
This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures.
Insulin-like growth factor binding protein (IGFBP) is a critical component of the insulin-like growth factor (IGF) family which regulate the biological functions of the IGFs and may also function in IGF-independent pathways. IGF-BP3 is a 30 kDa cysteine-rich secreted protein. It is the primary IGF binding protein found in the plasma of both humans and animals and is also stored in the α-granules of platelets. Beyond regulating the activity of IGF-I and IGF-II, IGFBP3 also inhibits the function of follicle-stimulating hormone (FSH). Low plasma levels of IGFBP3 are often associated with dwarfism, while elevated levels can contribute to conditions such as acromegaly. In fibroblasts, the expression of IGF-BP3 is upregulated by various mitogenic growth factors, including bombesin, vasopressin, platelet-derived growth factor (PDGF), and epidermal growth factor (EGF).
| Catalog No. | 105-01B3 |
|---|---|
| Country of Manufacture | China |
| Product Code | rhIGF-BP3 |
| Size/Quantity | 5 µg, 25 µg, 1mg |
| Product use | This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures. |
| Storage | Upon receipt, store at -20°C after receiving. Upon reconstitution, store at 2-8°C for up to one week. For maximal stability, aliquot and store at -20°C. Avoid repeated freeze/ thaw cycles. |
| Shipping | Gel ice. |
| Synonyms | Growth hormone dependent binding protein, IBP3, BP-53 |
| AA Sequence | GASSGGLGPV VRCEPCDARA LAQCAPPPAV CAELVREPGC GCCLTCALSE GQPCGIYTERC GSGLRCQPSP DEARPLQALL DGRGLCVNASA VSRLRAYLLP APPAPGNASES EEDRSAGEVE SPSVSSTHRVS DPKFHPLHSK IIIIKKGHAKD SQRYKVDYESQ STDTQNFSSE SKRETEYGPC RREMEDTLNH LKFLNVLSPR GVHIPNCDKK GFYKKKQCRP SKGRKRGFCW CVDKYGQPLP GYTTKGKEDV HCYSMQSK |
| Source | Escherichia coli |
| Molecular Weight | Approximately 28.8 kDa protein consisting of 264 amino acid residues. |
| Purity | >95% |
| Physical Appearance | White powder. |
| Formulation | Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4. |
| Endotoxin | <0.1 ng/μg of protein (<1 EU/μg) |
| Reconstitution | Reconstitute in sterile distilled water containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |
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