TCF/LEF GFP Reporter Vector
The TCF/LEF GFP reporter vector (TL-GFP) is a plasmid-based fluorescent reporter for real-time monitoring of Wnt/β-catenin–dependent transcription in mammalian cells
The Wnt/β-catenin pathway controls proliferation, differentiation, stem-cell maintenance, and tissue homeostasis, and its dysregulation is linked to cancer and developmental disorders. Upon Wnt activation, β-catenin accumulates in the cytoplasm and translocates to the nucleus, where it binds TCF/LEF (T cell factor/lymphoid enhancer factor family) transcription factors to activate target genes. The TCF/LEF GFP reporter vector (TL-GFP) is a plasmid-based fluorescent reporter for real-time monitoring of Wnt/β-catenin–dependent transcription in mammalian cells; it contains multimerized TCF/LEF response elements upstream of GFP so pathway activation induces GFP expression, enabling direct visualization of activity in living cells without lysis or extra detection reagents.
| Catalog No. | VT007 |
|---|---|
| Country of Manufacture | United States |
| Product Code | TL-GFP |
| Size/Quantity | 100 transfections 96-well |
| Product use | This product is for research use only. It is not approved for human or animal use, or for application in in vitro diagnostic procedures. |
| Storage | Upon receipt, store at -20°C. |
| Shipping | Room Temperature |
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