Human Gallbladder Vascular Endothelial Cells

Human Gallbladder Vascular Endothelial Cells (HGBVEC) perform essential physiological functions and are central to the pathogenesis of biliary diseases. These cells form a continuous, non-fenestrated vascular barrier that regulates the selective exchange of fluids and solutes—a critical process supporting the gallbladder’s primary role in storing and concentrating bile between meals. In the context of gallbladder cancer, the most common biliary tract malignancy, these cells undergo significant structural and functional remodeling. Driven by pro-angiogenic signals like VEGF, gallbladder endothelial cells facilitate the pathological angiogenesis and migration essential for tumor progression and high metastatic spread. Integrating signals from the unique, bile-rich microenvironment, gallbladder endothelial cells drive systemic disease through their dysfunction, making primary HGBVEC a reliable and biologically accurate model for researching biliary homeostasis and oncology. 

HGBVEC from ScienCell Research Laboratories are isolated from human gallbladder tissue. HGBVEC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 10⁵ cells in 1 ml volume. HGBVEC are characterized by immunofluorescence with antibodies specific to vWF/Factor VIII and/or CD31 (PECAM1). HGBVEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. HGBVEC are guaranteed to further culture under the conditions provided by ScienCell Research Laboratories; however, HGBVECs are not recommended for expanding or long-term cultures due to limited expansion capacity.