重组小鼠表皮生长因子

EGF was originally discovered in crude preparations of nerve growth factor prepared from mouse submaxillary glands as an activity that induced early eyelid opening, incisor eruption, hair growth inhibition, and stunting of growth when injected into newborn mice. EGF is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells. Additionally, EGF has been shown to inhibit gastric secretion, and to be involved in wound healing. EGF signals through a receptor known as c-erbB, which is a class I tyrosine kinase receptor. This receptor also binds with TGF-alpha and VGF (vaccinia virus growth factor).

表皮生长因子（EGF）最初是在从小鼠颌下腺制备的神经生长因子粗提物中发现的，其生物学活性表现为在新生小鼠体内诱导眼睑提前开启、门齿萌出、抑制毛发生长以及导致生长受限。EGF 是一种强效的生长因子，能够促进多种表皮及上皮细胞的增殖。此外，EGF 还被证实可抑制胃液分泌，并参与伤口愈合过程。EGF 通过其受体 c-erbB 介导信号传导，该受体属于 I 类酪氨酸激酶受体，同时也可与转化生长因子 α（TGF-α）及牛痘病毒生长因子（VGF）结合。