重组人转化生长因子-β2
重组人 TGF-β2 由两条相同的 112 个氨基酸多肽链组成，并通过一条二硫键相连，其分子量为 24.0 kDa。
Related Promotion:
There are three mammalian isoforms of transforming growth factor-beta (TGF-β), namely TGF-β1, TGF-β2, and TGF-β3. These multifunctional cytokines signal through the same receptor and elicit similar biological responses. They play crucial roles in regulating cell proliferation, growth, differentiation, motility, and the synthesis and deposition of the extracellular matrix. The release of the biologically active TGF-β isoform from a latent complex involves intracellular proteolytic processing. TGF beta 1, TGF beta 2, and TGF beta 1.2 exhibit similar biological activities, although they differ in receptor binding affinities. TGF beta 2 is found in high concentrations in platelets and bone. It is the prominent isoform in body fluids like amniotic fluid, breast milk, and the aqueous and vitreous humor of the eye. Recombinant Human TGF-β2 consists of two identical 112-amino acid polypeptide chains connected by a single disulfide bond and has a molecular weight of 24.0 kDa.
转化生长因子-β（TGF-β）在哺乳动物中主要有三种亚型：TGF-β1、TGF-β2 和 TGF-β3。这些多功能细胞因子通过相同的受体进行信号传导，并可引发相似的生物学反应。它们在调控细胞增殖、生长、分化、迁移以及细胞外基质的合成与沉积等过程中发挥重要作用。
生物活性 TGF-β 的释放需要通过细胞内蛋白水解过程，从其潜在复合物中被激活。尽管 TGF-β1、TGF-β2 和 TGF-β3 在受体结合亲和力上存在差异，但其生物学活性总体相似。
TGF-β2 在血小板和骨组织中含量较高，同时也是羊水、乳汁以及眼房水和玻璃体液等体液中的主要亚型。重组人 TGF-β2 由两条相同的 112 个氨基酸多肽链组成，通过一条二硫键连接，分子量约为 24.0 kDa。
| 目录编号 | 105-52 |
|---|---|
| 产品编码 | rhTGFb2 |
| 规格/数量 | 10 ug, 25 ug, 100 ug |
| 产品用途 | 本产品仅供研究使用。未经批准，不得用于人体、动物或体外诊断程序。 |
| 储存 | 收到后，请储存于 -20°C。复溶后，可在 2-8°C 保存最多一周。为获得最大稳定性，请分装并储存于 -20°C。避免反复冻融。 |
| 运输 | 凝胶包。 |
| Synonyms | Transforming Growth Factor-β2, Glioblastoma-derived T-cell suppressor factor, G-TSF, BSC-1 cell growth inhibitor, Polyergin, Cetermin |
| AA Sequence | ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHSR VLSLYNTINPE ASASPCCVSQ DLEPLTILYYI GKTPKIEQLSN MIVKSCKCS |
| Source | mammalian cell |
| Molecular Weight | 24.0 kDa, a disulfide bond linked non-glycosylated polypeptide chains containing two 112 amino acids |
| Purity | > 95% |
| Physical Appearance | Light yellow to white powder |
| Formulation | Lyophilized from a 0.2μm filtered concentrated (1mg/ml) solution in 30 mM Glycine-HCl and 100 mM NaCl with dextran as protectant. |
| Endotoxin | <0.1 ng/μg of protein (<1 EU/μg) |
| Reconstitution | Reconstitute in sterile distilled water or 0.04 M HCl containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |
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