重组人转化生长因子-β1
重组人TGF-β1由两条相同的112个氨基酸的多肽链组成，通过一条二硫键连接，分子量为25.0 kDa。
Related Promotion:
There are three mammalian isoforms of transforming growth factor-beta (TGF-β), namely TGF-β1, TGF-β2, and TGF-β3. These multifunctional cytokines signal through the same receptor and elicit similar biological responses. They play crucial roles in regulating cell proliferation, growth, differentiation, motility, and the synthesis and deposition of the extracellular matrix. The release of the biologically active TGF-β isoform from a latent complex involves intracellular proteolytic processing. TGF-β1 is the most abundant isoform that is secreted by nearly every cell type, and initially recognized for its ability to induce phenotypic transformation in fibroblasts. TGF-β1 has more recently been linked to skin tumor formation. Recombinant Human TGF-β1 consists of two identical 112-amino acid polypeptide chains connected by a single disulfide bond and has a molecular weight of 25.0 kDa.
哺乳动物中存在三种转化生长因子-β（TGF-β）亚型，分别为TGF-β1、TGF-β2和TGF-β3。这些多功能细胞因子通过相同的受体传递信号，并引发相似的生物学反应。它们在调控细胞增殖、成长、分化、运动性以及细胞外基质的合成和沉积中起关键作用。生物活性TGF-β亚型从潜在复合物释放的过程涉及细胞内的蛋白水解加工。TGF-β1是最丰富的亚型，几乎由所有细胞类型分泌，最初因其能够诱导成纤维细胞的表型转化而被发现。近年来，TGF-β1与皮肤肿瘤的形成也有关联。重组人TGF-β1由两条相同的112个氨基酸多肽链组成，通过一条二硫键连接，分子量为25.0 kDa。
| 目录编号 | 105-51 |
|---|---|
| 制造国家 | 美国 |
| 产品编码 | rhTGFb1 |
| 规格/数量 | 10ug, 50ug, 500ug |
| 产品用途 | 本产品仅供研究使用。未经批准，不得用于人体、动物或体外诊断程序。 |
| 储存 | 收到后请储存在 -20°C。复溶后可在 2-8°C 下保存最多一周。为确保最大稳定性，请分装并储存在 -20°C。避免反复冻融。 |
| 运输 | 凝胶包。 |
| Synonyms | Transforming Growth Factor-β1, Differentiation inhibiting factor, Cartilage-inducing factor |
| AA Sequence | ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHN PGASAAPCCV PQALEPLPIV YYVGRKPKVE QLSNMIVRSCKCS |
| Source | mammalian cell |
| Molecular Weight | 25.0 kDa, a disulfide bond linked non-glycosylated polypeptide chains containing two 112 amino acids |
| Purity | > 95% |
| Physical Appearance | Light yellow to white powder |
| Formulation | Lyophilized from a 0.2μm filtered concentrated (1mg/ml) solution in 30 mM sodium acetate, pH 3.0. |
| Endotoxin | <0.1 ng/μg of protein (<1 EU/μg) |
| Reconstitution | Reconstitute in sterile distilled water or 0.1 M HCl containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |
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