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Recombinant Human NRG-1 (EGF-like domain) Beta 1
Recombinant Human NRG-1 (EGF-like domain) Beta 1 (rhNRG-1b1) is an EGF family growth factor that activates ErbB receptors to regulate cell proliferation, survival, differentiation, cardiac function, neural development, and tissue regeneration.
Neuregulin-1 (NRG-1) is a member of the epidermal growth factor (EGF) family that regulates cell proliferation, differentiation, and survival through activation of ErbB receptor tyrosine kinases. The β1 isoform of the EGF-like domain specifically binds to ErbB3 and ErbB4 receptors, promoting heterodimerization with ErbB2 and initiating downstream signaling pathways including PI3K/Akt and MAPK.
NRG-1 β1 plays a critical role in cardiac development and maintenance by stimulating ErbB2/ErbB4 signaling in cardiomyocytes. It has been shown to induce ErbB receptor phosphorylation, promote cardiomyocyte survival, improve sarcomere organization, and facilitate intercalated disc remodeling. In addition to its cardiovascular functions, NRG-1 β1 is widely used in studies of neural development, Schwann cell biology, stem cell differentiation, and tissue regeneration.
| 目录编号 | 107-10b1 |
|---|---|
| 制造国家 | 美国 |
| 产品编码 | rhNRG-1b1 |
| 规格/数量 | 10ug, 50ug, 1mg |
| 产品用途 | This product is for research use only. It is not approved for human or animal use, or for application in in vitro diagnostic procedures. |
| 储存 | Upon receipt, store at -20°C after receiving. Upon reconstitution, store at 2-8°C for up to one week. For maximal stability, aliquot and store at -20°C. Avoid repeated freeze/ thaw cycles. |
| 运输 | Gel pack |
| Synonyms | NRG1-β1, HRGβ1, Heregulin β1, ARIA, HGL, HRG, HRGA, MST131, NDF |
| AA Sequence | SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE |
| Source | E. coli |
| Molecular Weight | 7.5 kDa |
| Purity | > 95% |
| Physical Appearance | White lyophilized powder. |
| Formulation | Lyophilized from a 0.2µm filtered concentrated solution in 20 mM Tris-HCl pH7.5 and 300 mM NaCl with dextran as protectant. |
| Endotoxin | <0.1 ng/μg of protein (<1 EU/μg) |
| Reconstitution | Reconstitute in sterile distilled water or 1x PBS containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |
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