Recombinant Human Cereblon
ScienCell’s Recombinant Human Cereblon (6xHis-CRBN) is for research use only. It is not approved for human or animal use, or for application in clinical or in vitro diagnostic procedures.
Human Cereblon (CRBN) serves as the substrate receptor of the DDB1-CUL4-RBX1 (CRL4CRBN) E3 ubiquitin ligase complex, where it mediates the recognition and ubiquitination of numerous target proteins, including ILF2 and MEIS2. Upon substrate binding, CRBN recruits target proteins to the E3 ligase complex, promoting their ubiquitination and subsequent degradation by the proteasome. CRBN regulates the stability of diverse cellular proteins, including transcription factors, growth regulators, and kinases. Through its central role in protein homeostasis, CRBN influences multiple signaling pathways involved in development, immunity, and cancer. In addition, CRBN has emerged as a key therapeutic target and is widely studied in targeted protein degradation technologies (PROTACs).
This recombinant CRBN was engineered from the wild type CRBN and has a N-terminal His-tag.
| 目录编号 | MB7708 |
|---|---|
| 制造国家 | 美国 |
| 产品编码 | 6xHis-CRBN |
| 规格/数量 | 25 ug or 100 ug |
| 产品用途 | This product is for research use only. It is not approved for human or animal use, or for application in in vitro diagnostic procedures. |
| 储存 | Upon receipt, store at -20°C in a manual defrost freezer. |
| 运输 | Dry ice. |
| Synonyms | Protein cereblon, AD-006, CRBN |
| Source | Escherichia coli |
| Molecular Weight | 38 kDa |
| Purity | > 95% |
