人口腔成纤维细胞
ScienCell Research Laboratories 的 人口腔成纤维细胞（HOrF） 分离自人口腔组织，于第一代（P1）进行冻存，并以冷冻状态提供。每瓶含有 >5 × 105 个细胞，体积为 1 mL。
Fibroblasts are mesenchymal cells which perform many vital functions during development and in adulthood. They are responsible for much of the synthesis of extracellular matrix in connective tissue and play major roles in wound healing. Many diseases are associated with fibroblasts, either because fibroblasts are implicated in their etiology or because of the fibrosis that accompanies damage to other cell types. Human oral fibroblasts (HOrF), located in the oral cavity, have the ability to rapidly repair defects in the oral cavity. HOrF, in contrast to skin fibroblasts, can more quickly reorganize the extracellular matrix and migrate for wound repair. Abnormal proliferation of HOrF can lead to the development of oral squamous cell carcinoma. HOrF are a useful model for elucidating the mechanisms of fibrosis and developing treatments for oral cancers.
HOrF from ScienCell Research Laboratories are isolated from human oral tissue. HOrF are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. HOrF are characterized by their spindle morphology and immunofluorescence with antibodies specific to fibronectin. HOrF are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HOrF are guaranteed to further expand for 15 population doublings under the conditions provided by ScienCell Research Laboratories.
Recommended Medium
It is recommended to use Fibroblast Medium (FM, Cat. #2301) for the culturing of HOrF in vitro.
成纤维细胞是间充质细胞，在发育过程中以及成年后发挥多种重要功能。它们负责结缔组织中大部分细胞外基质的合成，并在伤口愈合过程中发挥重要作用。许多疾病与成纤维细胞有关，这可能是因为成纤维细胞参与了疾病的发生机制，也可能是因为其他细胞类型受损后伴随发生纤维化。位于口腔内的人口腔成纤维细胞（HOrF）具有快速修复口腔组织缺损的能力。与皮肤成纤维细胞相比，HOrF 能够更快地重组细胞外基质并迁移，从而促进伤口修复。HOrF 的异常增殖可能导致口腔鳞状细胞癌的发生。HOrF 可作为研究纤维化机制以及开发口腔癌治疗方法的有用模型。
ScienCell Research Laboratories 的 HOrF 分离自人口腔组织，于第一代（P1）进行冻存，并以冷冻状态提供。每瓶含有 >5 × 105 个细胞，体积为 1 mL。HOrF 通过其梭形细胞形态以及采用针对纤连蛋白（fibronectin）的特异性抗体进行免疫荧光染色来表征。HOrF 经检测为 HIV-1、HBV、HCV、支原体、细菌、酵母菌和真菌阴性。在 ScienCell Research Laboratories 提供的培养条件下，HOrF 可进一步扩增至少 15 个群体倍增。
推荐培养基
建议使用成纤维细胞培养基（FM，产品编号 2301）进行 HOrF 的体外培养。
| 目录编号 | 2640 |
|---|---|
| 制造国家 | 美国 |
| 产品编码 | HOrF |
| 规格/数量 | 5 x 10^5 cells/vial |
| 产品用途 | 本产品仅供研究使用。未经批准，不得用于人体、动物或体外诊断程序。 |
| 储存 | 收到后，立即将细胞从干冰转移到液氮中，并在液氮中保存，直到需要进行实验。 |
| 运输 | 干冰。 |
ScienCell Research Laboratories (SRL) takes pride in being a resource for researchers all over the world. The publications listed here are not meant as an endorsement or confirmation of the reliability of the products.
