GABRA2 - Genotype-Defined Cells - Primary Cells

GABRA2

Why This Genotype Matters

Why GABRA2 rs279858 Matters

GABRA2 encodes the α2 subunit of the GABA-A receptor, a major mediator of fast inhibitory neurotransmission in the CNS. Variation within GABRA2 has been investigated in studies of GABA-A receptor biology and neuropsychiatric phenotypes.

The rs279858 variant has also been associated with differences in GABRA2 expression in human neural cell models, with C-allele carriers showing lower GABRA2 mRNA expression than T/T lines in one study.

For researchers studying genotype-dependent neuronal phenotypes, using donors with a confirmed rs279858 genotype provides a defined genetic variable for experimental comparison rather than leaving this locus uncharacterized.

Available Genotypes

GABRA2 Genotype-Defined Human Neurons

Cell Type	Catalog No.	GABRA2 rs279858
Human Neurons	Cat. #1520	T/T C/T C/C

Each selected lot is accompanied by a Certificate of Analysis (COA) confirming the requested donor genotype.

Why Genotype-Defined Primary Human Neurons

Understanding Genotype-Associated Neuronal Differences

Traditional primary cell studies can involve substantial donor-to-donor genetic variation. When a genetic locus relevant to the research question is unknown, differences between donors may become an uncontrolled experimental variable.

Genotype-defined neurons provide a more intentional study design:

Defined genotype

Select donors based on a confirmed variant.

Controlled comparison

Compare genotype backgrounds under matched experimental conditions

Functional investigation

Measure differences in expression, signaling, cellular phenotype, or compound response

Human primary-cell context

Evaluate genotype-associated biology in primary human neurons

This approach does not eliminate donor-to-donor biological variability, but it allows researchers to account for genotype at a specific locus of interest when designing and interpreting experiments.

Research Applications

From Genetic Stratification to Functional Studies

Genotype-defined primary human neurons can help researchers investigate whether genetic background is associated with differences in:

GABRA2 expression and genotype–phenotype studies in primary human neurons

GABA-A receptor α2 subunit biology and receptor-related phenotypes

GABAergic signaling and genotype-associated inhibitory neuronal responses

Neuronal excitability and synaptic function across defined donor backgrounds

Pharmacological response to GABAergic compounds and receptor modulators

Transcriptomic profiling of genotype-associated molecular differences

The defined genotype can be incorporated as an experimental variable alongside treatment, disease model, or other study conditions.

How to Order

Requesting Genotype-Defined Lots

Genotype-defined lots are available by request. Lot availability varies by genotype. A selection and verification fee applies per vial and will be reflected in your quote.

Identify the Cell Type

Select Human Neurons (Cat. #1520).

Specify GABRA2 Genotype

Indicate the variant and genotype required for your study: GABRA2 rs279858: T/T, T/C, or C/C

Submit Your Request

Our team will confirm current lot availability and provide a quote with COA documentation.

Need Help With Genotype Selection?

Please note that availability varies by genotype and donor lot. A selection and verification fee will be applied per vial and reflected in your quote.

For information on available genotypes, assistance selecting the right cells, or inquiries about additional genotypes and cell types, please contact us at info@sciencellonline.com, or call 1.877.602.8549.