Recombinant Human Fibroblast Growth Factor-21
This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures.
Fibroblast growth factor 21 (FGF-21) belongs to the large FGF family which has at least 23 members. However, FGF-21, along with FGF-19 and FGF-23, belongs to a subfamily of atypical FGFs where it lacks a conventional heparin-binding motif. In the presence of β Klotho as a cofactor, FGF-21 signals via the FGFR1c and 4 receptors to induce glucose uptake by adipocytes. This novel metabolic regulator acts as an endocrine hormone and is predominantly produced in liver upon the induction of peroxisome proliferator-activator receptors, PPAR α and PPAR α.
| Catalog No. | 104-21 |
|---|---|
| Country of Manufacture | China |
| Product Code | rhFGF-21 |
| Size/Quantity | 5ug, 20ug, or 1mg |
| Product use | This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures. |
| Storage | Store at -20°C after receiving. Upon reconstitution, store at 2-8°C for up to one week. For maximal stability, aliquot and store at -20°C. Avoid repeated freeze/ thaw cycles. |
| Shipping | Dry ice. |
| Synonyms | FGF21 |
| AA Sequence | MHPIPDSSPL LQFGGQVRQR YLYTDDAQQT EAHLEIREDG TVGGAADQSPESLLQLKALK PGVIQILGVK TSRFLCQRPD GALYGSLHFD PEACSFRELLLEDGYNVYQS EAHGLPLHLP GNKSPHRDPA PRGPARFLPL PGLPPALPEPPGILAPQPPD VGSSDPLSMV GPSQGRSPSY AS |
| Source | Escherichia coli |
| Molecular Weight | Approximately 19.5 kDa, a single non-glycosylated polypeptide chain containing 182 amino acids. |
| Purity | >95% by SDS-PAGE and HPLC analyses. |
| Biological Activity | Fully biologically active. The ED50 is 0.06-0.4ug/ml in the presence of β Klotho and Heparin, as determined by proliferation of BaF3 cells. |
| Physical Appearance | White lyophilized powder. |
| Formulation | Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4. |
| Endotoxin | < 1EU/μg of growth factor as determined by LAL method. |
| Reconstitution | Reconstitute in sterile distilled water containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |
No Publication available at this time.