Recombinant Hamster Epidermal Growth Factor
Recombinant Hamster Epidermal Growth Factor (rcEGF) is for research use only. It is not approved for human or animal use, or for application in clinical or in vitro diagnostic procedures.
Epidermal Growth Factor (EGF) is a small, mitogenic polypeptide that plays a central role in inducing cell growth, proliferation, differentiation, and survival. The full length EGF protein (EGF precursor) contains nine EGF domains and nine LDLR class B repeats. The mature protein is much smaller, about 53 aa, and is generated by proteolytic cleavage of the EGF domain proximal to the transmembrane region. EGF exerts its biological effects by binding to the epidermal growth factor receptor (EGFR), inducing the dimerization of the EGF receptor to activate downstream protein tyrosine kinase signaling pathway. EGF is well conserved across mammals with mature hamster EGF 85% identical to mature human EGF and about 80% to mature mouse and rat EGFs.
| Catalog No. | 185-04 |
|---|---|
| Country of Manufacture | United States |
| Product Code | rcEGF |
| Size/Quantity | 100 μg and 500 μg |
| Product use | This product is for research use only. It is not approved for human or animal use, or for application in in vitro diagnostic procedures. |
| Storage | Upon receipt, store at -20°C after receiving. Upon reconstitution, store at 2- 8°C for up to one week. For maximal stability, aliquot and store at -20°C. Avoid repeated freeze/ thaw cycles. |
| Shipping | Gel pack |
| Synonyms | Urogastrone, URG |
| AA Sequence | NSNPGCPPSHDGYCLHGGVCMYVEAVDSYACN CIVGYVGERCQHRDLRWWELR |
| Source | Escherichia coli |
| Molecular Weight | 6 kDa, a single non-glycosylated polypeptide chain containing 53 amino acids |
| Purity | > 95% |
| Physical Appearance | White powder |
| Formulation | Lyophilized from a 0.2µm filtered concentrated solution in PBS, with Dextran as protectant. |
| Endotoxin | <0.1 ng/μg of protein (<1 EU/μg) |
| Reconstitution | Reconstitute in sterile distilled water containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |
No Publication available at this time.
