Recombinant Human Interferon-alpha2b
IFN-αs are proteins secreted by leukocyte. They are mainly involved in innate immune response against viral infection.
IFN-αs are proteins secreted by leukocyte. They are mainly involved in innate immune response against viral infection. The IFN-α family has 13 subtypes and 23 different variants. The individual proteins have molecular masses between 19-26 kDa and consist of proteins with lengths of 156-166 and 172 amino acids. All IFN-α subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino-terminal ends are variable. Many IFN-alpha subtypes differ in their sequences at only one or two positions. IFN-α2b differs from IFN-α2a by a single amino acid (the substitution of arginine for lysine at position 23), which makes up a potentially and clinically relevant difference, involving its immunogenicity.
| Catalog No. | 106-04 |
|---|---|
| Country of Manufacture | United States |
| Product Code | rhIFN-α2b |
| Size/Quantity | 10 μg, 100 μg, or 1 mg |
| Product use | This product is for research use only. It is not approved for human or animal use, or for application in vitro diagnostic procedures. |
| Storage | Store at -20°C after receiving. Upon reconstitution, store at 2-8°C for up to one week. For maximal stability, aliquot and store at -20°C. Avoid repeated freeze/ thaw cycles. |
| Shipping | Gel pack |
| Synonyms | Interferon-alpha2b, IFN-α2b |
| AA Sequence | SCDLPQTHSL GSRRTLMLLA QMRRISLFSC LKDRHDFGFP QEEFGNQFQK AETIPVLHEM IQQIFNLFST KDSSAAWDET LLDKFYTELY QQLNDLEACV IQGVGVTETP LMKEDSILAV RKYFQRITLY LKEKKYSPCA WEVVRAEIMR SFSLSTNLQE SLRSKE |
| Source | Escherichia coli |
| Molecular Weight | 19.2 kDa, a single non-glycosylated polypeptide chain containing 166 amino acids |
| Purity | > 95% |
| Physical Appearance | White lyophilized powder. |
| Formulation | Lyophilized from a 0.2µm filtered concentrated (1mg/ml) solution in PBS, pH 7.4. |
| Endotoxin | <0.1 ng/μg of protein (<1 EU/μg) |
| Reconstitution | Reconstitute in sterile distilled water containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |
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