Recombinant Human Fibroblast Growth Factor 8
Recombinant Human Fibroblast Growth Factor 8 (rhFGF8) is a secreted, heparin-binding member of the FGF family, originally identified as an androgen-dependent growth factor in mouse mammary carcinoma cells.
Recombinant Human Fibroblast Growth Factor 8 (FGF8) is a secreted, heparin-binding member of the FGF family, originally identified as an androgen-dependent growth factor in mouse mammary carcinoma cells. In humans, four isoforms (FGF8a, b, e, f) are produced by alternative splicing. FGF8 plays a critical role during embryogenesis, regulating epithelial–mesenchymal transition and orchestrating tissue patterning of the midbrain/hindbrain, eye, ear, limbs, and heart. In adults, FGF8 expression is limited, but detectable in reproductive and genitourinary tissues, bone marrow hematopoietic cells, and peripheral leukocytes. Recombinant Human Fibroblast Growth Factor 8 (FGF8) corresponds to amino acids Gln23–Arg244 of the human FGF8 protein, with an additional N-terminal Met and C-terminal His tag, giving a total length of 202 amino acids.
| Catalog No. | 104-08 |
|---|---|
| Country of Manufacture | United States |
| Product Code | rhFGF8 |
| Size/Quantity | 10 ug, 100 ug and 1 mg |
| Product use | This product is for research use only. It is not approved for human or animal use, or for application in in vitro diagnostic procedures. |
| Storage | Upon receipt, store at -20°C after receiving. Upon reconstitution, store at 2-8°C for up to one week. For maximal stability, aliquot and store at -20°C. Avoid repeated freeze/ thaw cycles. |
| Shipping | Gel Ice. |
| Synonyms | FGF8, HBGF-8, AIGF |
| AA Sequence | MQVTVQSSPN FTQHVREQSLV TDQLSRRLIR TYQLYSRTSG KHVQVLANKR INAMAEDGDP FAKLIVETDT FGSRVRVRGA ETGLYICMNK KGKLIAKSNG KGKDCVFTEI VLENNYTALQ NAKYEGWYMA FTRKGRPRKG SKTRQHQREV HFMKRLPRGH HTTEQSLRFE FLNYPPFTRS LRGSQRTWAP EPRLEHHHHHH |
| Source | E. coli |
| Purity | > 95% |
| Physical Appearance | Light yellow to white powder |
| Formulation | Lyophilized from a 0.2µm filtered concentrated (1mg/ml) solution in 1x PBS with dextran as protectant. |
| Endotoxin | <0.1 ng/μg of protein (<1 EU/μg) |
| Reconstitution | Reconstitute in sterile distilled water or sterile 1x PBS containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |
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