Recombinant Rat IGF-1
This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures.
The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro via stimulating the uptake of glucose, fatty acids and amino acids. The liver predominantly produces IGFs, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-I binds to Type I IGF receptor, a homolog of the insulin receptor.
| 目录编号 | 145-01 |
|---|---|
| 产品编码 | rrIGF-I |
| 制造国家 | United States or China |
| 规格/数量 | 10ug, 50ug, 1mg |
| 产品用途 | 本产品仅供研究使用。未经批准，不得用于人体、动物或体外诊断程序。 |
| 储存 | 收到后，请储存于 -20°C。复溶后，可在 2-8°C 保存最多一周。为获得最大稳定性，请分装并储存于 -20°C。避免反复冻融。 |
| 运输 | 干冰。 |
| Synonyms | IGF1, IGF-1, IGFI, Somatamedin C |
| AA Sequence | GPETLCGAEL VDALQFVCGP RGFYFNKPTG YGSSIRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPTKSA |
| Source | Escherichia coli |
| Molecular Weight | Approximately 7.6 kDa, a single non-glycosylated polypeptide chain containing 70 amino acids. |
| Purity | >95% by SDS-PAGE and HPLC analyses. |
| Biological Activity | Fully biologically active. The ED50 is < 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg, as determined by FDC-P1 cell proliferation. |
| Physical Appearance | White lyophilized powder. |
| Formulation | Lyophilized from a 0.2μm filtered concentrated solution in 20mM PBS, pH 7.0. |
| Endotoxin | < 1EU/μg of growth factor as determined by LAL method. |
| Reconstitution | Reconstitute in sterile distilled water containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |