重组人血管内皮生长因子165
重组人血管内皮生长因子165（rhVEGF165）产品仅供科研用途，不得用于人类、动物或体外诊断程序。
Related Promotion:
VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product.
VEGF是一种强效的生长和血管生成细胞因子。它能够刺激内皮细胞的增殖和存活，并促进血管生成及血管通透性。在血管丰富的组织中表达的VEGF，在正常及病理性血管生成中发挥重要作用。大量证据表明，VEGF与肿瘤转移及眼内新生血管综合征的发生密切相关。VEGF通过三种受体发挥信号作用：类Fms酪氨酸激酶受体（flt-1）、KDR基因产物（小鼠同源物为flk-1基因产物）以及flt4基因产物。
| 目录编号 | 105-05 |
|---|---|
| 产品编码 | rhVEGF165 |
| 制造国家 | United States or China |
| 规格/数量 | 2ug, 10ug, 1mg |
| 产品用途 | 本产品仅供研究使用。未经批准，不得用于人体、动物或体外诊断程序。 |
| 储存 | 收到后，请储存于 -20°C。复溶后，可在 2-8°C 保存最多一周。为获得最大稳定性，请分装并储存于 -20°C。避免反复冻融。 |
| 运输 | 干冰。 |
| AA Sequence | APMAEGGGQN HHEVVKFMDV YQRSYCHPIE TLVDIFQEYP DEIEYIFKPS CVPLMRCGGC CNDEGLECVP TEESNITMQI MRIKPHQGQH IGEMSFLQHN KCECRPKKDR ARQENPCGPC SERRKHLFVQ DPQTCKCSCK NTDSRCKARQ LELNERTCRC DKPRR |
| Source | Escherichia coli |
| Molecular Weight | Approximately 38.2 kDa disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains. |
| Purity | >95% by SDS-PAGE and HPLC analyses. |
| Biological Activity | Fully biologically active. The ED50 is 1-8ng/ml, as determined by HUVEC cell proliferation. |
| Physical Appearance | White lyophilized powder. |
| Formulation | Lyophilized from a 0.2μm filtered solution in PBS, pH 7.4. |
| Endotoxin | < 1EU/μg of growth factor as determined by LAL method. |
| Reconstitution | Reconstitute in sterile distilled water containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |