Stem Cell Factor (SCF) plays essential roles in gametogenesis, melanogenesis and early stages of hematopoiesis. In in vitro and in vivo, SCF can stimulate the proliferation of mature, as well as the proliferation and maturation of immature, mast cells. On purified primitive human and mouse hematopoietic precursors, SCF acts in a synergistic manner with various growth factors, such as IL-1, IL-3, IL-6, IL-7, and Epo, to induce myeloid, erythroid and lymphoid lineage colony formation.
干细胞因子（SCF）在生殖细胞生成、黑色素生成以及造血早期阶段中发挥关键作用。在体外和体内实验中，SCF可促进成熟肥大细胞的增殖，以及未成熟肥大细胞的增殖和成熟。在纯化的人类和小鼠原始造血前体细胞中，SCF可与多种生长因子（如IL-1、IL-3、IL-6、IL-7和促红细胞生成素Epo）协同作用，诱导髓系、红系和淋系谱系的集落形成。
| 目录编号 | 102-01 |
|---|---|
| 产品编码 | rhSCF |
| 制造国家 | United States or China |
| 规格/数量 | 2ug, 10ug, or 1mg |
| 产品用途 | 本产品仅供研究使用。未经批准，不得用于人体、动物或体外诊断程序。 |
| 储存 | 收到后，请储存于 -20°C。复溶后，可在 2-8°C 保存最多一周。为获得最大稳定性，请分装并储存于 -20°C。避免反复冻融。 |
| 运输 | 干冰。 |
| Synonyms | Mast Cell Growth factor (MGF), c-kit Ligand and Steel-Factor (SLF) |
| AA Sequence | MEGICRNRVT NNVKDVTKLV ANLPKDYMIT LKYVPGMDVL PSHCWISEMV VQLSDSLTD LDKFSNISEG LSNYSIIDKL VNIVDDLVEC VKENSSKDLK KSFKSPEPRL FTPEEFFRIF NRSIDAFKDF VVASETSDCV VSSTLSPEKD SRVSVTKPFM LPPVA |
| Source | Escherichia coli. |
| Molecular Weight | Approximately 18.4 kDa, a single non-glycosylated polypeptide chain containing 165 amino acids. |
| Purity | >97% by SDS-PAGE and HPLC analyses. |
| Biological Activity | Fully biologically active. The ED50 is < 10ng/ml, corresponding to a specific activity of ≥ 1 x 105 units/mg, as determined by proliferation of BAF3 cells expressing FGF receptors |
| Physical Appearance | White lyophilized powder. |
| Formulation | Lyophilized from a 0.2µm filtered concentrated (0.5mg/ml) solution in PBS, pH 7.4. |
| Endotoxin | Less than 1EU/µg of rHuOPG-Fc as determined by LAL method. |
| Reconstitution | Reconstitute in sterile distilled water containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |