重组人血小板衍生生长因子-BB
血小板衍生生长因子（PDGF）最早于1980年代末由Lynch及其团队在动物研究中发现，其存在于血清中但血浆中缺失。PDGF为二硫键连接的二聚体，由两条多肽链组成，即A链和B链。PDGF具有三种亚型：PDGF-AA、PDGF-BB和PDGF-AB。
Platelet-derived growth factor (PDGF) presenting in serum but absent from plasma was first discovered in animal study by Lynch and co-workers in the late 1980s. It is a disulfide-linked dimer consisting of two peptides-chain A and chain B. PDGF has three subforms: PDGF-AA, PDGF-BB, PDGF-AB. It is involved in a number of biological processes, including hyperplasia, embryonic neuron development, chemotaxis, and respiratory tubule epithelial cell development. The function of PDGF is mediated by two receptors (PDGFR-α and PDGFR-β).
血小板衍生生长因子（PDGF）最早于1980年代末由Lynch及其团队在动物研究中发现，其存在于血清中但血浆中缺失。PDGF为二硫键连接的二聚体，由A链和B链两条多肽组成。PDGF具有三种亚型：PDGF-AA、PDGF-BB和PDGF-AB。它参与多种生物过程，包括细胞增生、胚胎神经元发育、趋化性及呼吸小管上皮细胞发育。PDGF的功能通过两种受体介导：PDGFR-α 和 PDGFR-β。
| 目录编号 | 105-10 |
|---|---|
| 制造国家 | 美国 |
| 产品编码 | rhPDGF-BB |
| 规格/数量 | 10 μg, 50 μg, or 500 μg |
| 产品用途 | 本产品仅供研究使用。未经批准，不得用于人体、动物或体外诊断程序。 |
| 储存 | 收到后，请储存于 -20°C。复溶后，可在 2-8°C 保存最多一周。为获得最大稳定性，请分装并储存于 -20°C。避免反复冻融。 |
| 运输 | 凝胶包。 |
| Synonyms | Platelet-Derived Growth Factor-BB, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF) |
| AA Sequence |
(monomer)
SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV VRKIEIVRK KPIFKKATVT LEDHLACKCE TVAAARPVT |
| Source | Yeast |
| Molecular Weight | Approximately 24.3 kDa, a disulfide-linked homodimeric protein containing two 110 amino acids residues polypeptide. |
| Purity | > 95% by SDS-PAGE |
| Physical Appearance | White lyophilized powder. |
| Formulation | Lyophilized from a 0.2µm filtered concentrated (1mg/ml) solution in PBS, pH 7.4. |
| Endotoxin | <0.1 ng/μg of protein (<1 EU/μg) |
| Reconstitution | Reconstitute in sterile distilled water containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |