重组人肿瘤抑制素 M（Oncostatin M）, 227个氨基酸

Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSH can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptor in hepatoma cells. OSM share several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells.

肿瘤抑制素 M（Oncostatin M，OSM）是一种参与神经发生、成骨作用及造血调控的生长与分化因子。OSM 由活化的 T 细胞、单核细胞以及卡波西肉瘤细胞产生，对细胞增殖既可产生促进作用，也可发挥抑制作用。它可促进成纤维细胞、平滑肌细胞及卡波西肉瘤细胞的增殖，同时抑制部分正常细胞及肿瘤细胞系的生长。此外，OSM 还能促进内皮细胞释放细胞因子（如 IL-6、GM-CSF 和 G-CSF），并增强肝癌细胞中低密度脂蛋白受体的表达。OSM 在结构和功能上与白血病抑制因子（LIF）、白细胞介素-6（IL-6）及睫状神经营养因子（CNTF）具有一定相似性。人源 OSM 对小鼠细胞同样具有活性。