Recombinant Human NFkB
Upon activation by environmental stimuli such as stress, cytokines, bacterial or viral molecules, NFkB complex could translocate into the nucleus and bind to target DNA, regulating gene expression involved in inflammatory reactions, immune responses, cell proliferation and differentiation, and apoptosis.
NFkB(p50) belongs to the superfamily of human NFkB transcription factors. NFkB family members include p50/p105, p52/p100, RelA(p65), RelB and cRel. NFkB(p50) associates with NFkB family members to form homo- or heterodimers. Upon activation by environmental stimuli such as stress, cytokines, bacterial or viral molecules, NFkB complex could translocate into the nucleus and bind to target DNA, regulating gene expression involved in inflammatory reactions, immune responses, cell proliferation and differentiation, and apoptosis.
| 目录编号 | MB9128 |
|---|---|
| 制造国家 | 美国 |
| 产品编码 | rhNFkB |
| 规格/数量 | 10 μg, 100 μg, or 500 μg |
| 产品用途 | 本产品仅供研究使用。未经批准，不得用于人体、动物或体外诊断程序。 |
| 储存 | 复溶后，在 2–8°C 保存最多一周。为获得最大稳定性，请分装并存放于 -20°C。避免反复冻融。 |
| 运输 | 凝胶冰袋。 |
| Synonyms | NFkB1, NF kappaB, NF kappa B, NFkB p50, NFkB p105, Nuclear factor kappa B, EBP-1. |
| AA Sequence | MGSSHHHHHHSSGLVPRGSHMAEDDPYLGRPEQMFHLDP SLTHTIFNPEVFQPQMALPTDGPYLQILEQPKQRGFRFRYV CEGPSHGGLPGASSEKNNKSYPQVKICNYVGPAKVIVQLV TNGKNIHLHAHSLVGKHCEDGICTVTAGPKDMVVGFANL GILHVTKKKVFETLEARMTEACIRGYNPGLLVHPDLAYLQ AEGGGDRQLGDREKELIRQAALQQTKEMDLSVVRLMFTA FLPDSTGSFTRRLEPVVSDAIYDSKAPNASNLKIVRMDRTA GCVTGGEEIYLLCDKVQKDDIQIRFYEEEENGGVWEGFGD FSPTDVHRQFAIVFKTPKYKDINITKPASVFVQLRRKSDLET SEPKPFLYYPEIKDKEEVQRKRQKLMPNFSDSFGGGSGAG AGGGGMFGSGGGGGGTGSTGPGYSFPHYGFPTYGGITFHP GTTKSNAGMKHG |
| Source | Escherichia coli |
| Molecular Weight | Approximately 49.7 kDa |
| Purity | > 95% by SDS-PAGE |
| Physical Appearance | White lyophilized powder. |
| Formulation | Lyophilized from a 0.2µm filtered solution in PBS, pH 7.4. |
| Endotoxin | <0.1 ng/μg of protein (<1 EU/μg) |
| Reconstitution | Reconstitute in sterile distilled water or saline. |
