M-CSF is a four α helical bundle cytokine that is the primary regulator of macrophage survival, proliferation and differentiation. M-CSF is also essential for the survival and proliferation of osteoclast progenitors. M-CSF also primes and enhances macrophage killing of tumor cells and microorganisms, regulates the release of cytokines and other inflammatory modulators from macrophages, and stimulates pinocytosis.
M-CSF是一种由四个α螺旋结构组成的细胞因子，是调控巨噬细胞存活、增殖和分化的关键因子。M-CSF对于破骨细胞前体的存活和增殖同样至关重要。此外，M-CSF还可增强巨噬细胞对肿瘤细胞和微生物的杀伤能力，调节巨噬细胞释放细胞因子及其他炎症介质，并促进胞饮作用。
| 目录编号 | 102-09 |
|---|---|
| 产品编码 | rhM-CSF |
| 制造国家 | United States or China |
| 规格/数量 | 2ug, 10ug, or 1mg |
| 产品用途 | 本产品仅供研究使用。未经批准，不得用于人体、动物或体外诊断程序。 |
| 储存 | 收到后，请储存于 -20°C。复溶后，可在 2-8°C 保存最多一周。为获得最大稳定性，请分装并储存于 -20°C。避免反复冻融。 |
| 运输 | 干冰。 |
| Synonyms | CSF-1, Lanimostim |
| AA Sequence | EEVSEYCSHM IGSGHLQSLQ RLIDSQMETS CQITFEFVDQ EQLKDPVCYL KKAFLLVQDI MEDTMRFRDN TPNAIAIVQL QELSLRLKSC FTKDYEEHDKACVRTFYETP LQLLEKVKNV FNETKNLLDK DWNIFSKNCN NSFAECSSQ |
| Source | Baculovirus infected Silkworm |
| Molecular Weight | Approximately 42.0 kDa, a covalently linked homodimer, of two 21.0 kDa polypeptide monomers (1-149 amino acid of human M-CSF). |
| Purity | >95% by SDS-PAGE and HPLC analyses. |
| Biological Activity | Fully biologically active. The ED50 is < 3ng/ml, as determined by murine M-NSF-60 proliferation. |
| Physical Appearance | White lyophilized powder. |
| Formulation | Lyophilized from a 0.2μm filtered solution in 20mM PB, containing 1% HSA and 3% Mannitol. |
| Endotoxin | < 1EU/μg of growth factor as determined by LAL method. |
| Reconstitution | Reconstitute in sterile distilled water containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |