重组人 Long R3 胰岛素样生长因子-1

Insulin-like growth factor-1 (IGF-1) is the principal hormonal mediator of statural growth. Under normal circumstances, growth hormone (GH) binds to its receptor in the liver, and other tissues, and stimulates the synthesis/secretion of IGF-1. In target tissues, the Type 1 IGF receptor, which is homologous to the insulin receptor, is activated by IGF-1, leading to intracellular signaling which stimulates multiple processes leading to statural growth. The metabolic actions of IGF-1 are in part directed at stimulating the uptake of glucose, fatty acids, and amino acids so that metabolism supports growing tissues. The LR3 is a long-term analog of human IGF-1, specifically designed and manufactured for mammalian cell culture to support large-scale manufacturing of recombinant biopharmaceuticals.

胰岛素样生长因子-1（IGF-1）是调节机体生长发育的主要激素介质。在正常情况下，生长激素（GH）与肝脏及其他组织中的受体结合后，可刺激 IGF-1 的合成与分泌。

在靶组织中，与胰岛素受体同源的 I 型 IGF 受体会被 IGF-1 激活，从而启动细胞内信号传导，促进多种与生长发育相关的生物过程。IGF-1 的代谢作用部分体现在促进葡萄糖、脂肪酸和氨基酸的摄取，以支持生长组织的代谢需求。

LR3 是人 IGF-1 的一种长效类似物，专门设计并生产用于哺乳动物细胞培养，可支持重组生物制药产品的大规模生产。