Recombinant Human Keratinocyte Growth Factor-1
This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures.
Keratinocyte Growth Factor-1 (KGF-1) is one of the 23 known members of the FGF family. All FGFs have two conserved cysteine residues and share 30 - 50% sequence identity at the amino acid level. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of variety of tissues, by promoting cellular proliferation and differentiation. KGF-1 is a mitogen factor specific for epithelial cells and keratinocytes and signals through FGF receptor 2b. KGF-1 is important in kidney and lung development, angiogenesis, and wound healing.
| 目录编号 | 104-07 |
|---|---|
| 产品编码 | rhKGF-1 |
| 制造国家 | United States or China |
| 规格/数量 | 2µg, 10µg, 1mg |
| 产品用途 | 本产品仅供研究使用。未经批准，不得用于人体、动物或体外诊断程序。 |
| 储存 | 收到后，请储存于 -20°C。复溶后，可在 2-8°C 保存最多一周。为获得最大稳定性，请分装并储存于 -20°C。避免反复冻融。 |
| 运输 | 干冰。 |
| Synonyms | FGF-7, HBGF-7 |
| AA Sequence | MCNDMTPEQM ATNVNCSSPE RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE MKNNYNIMEI RTVAVGIVAI KGVESEFYLA MNKEGKLYAK KECNEDCNF KELILENHY NTYASAKWT HNGGEMFVAL NQKGIPVRGK KTKKEQKTAH FLPMAIT |
| Source | Escherichia coli |
| Molecular Weight | Approximately 19.0 kDa, a single, non-glycosylated polypeptide chain containing 164 amino acids. |
| Purity | >96% by SDS-PAGE and HPLC analyses. |
| Biological Activity | Fully biologically active. The ED50 is < 10ng/ml, corresponding to a specific activity of ≥ 1 x 10^5 units/mg, as determined by proliferation of BaF3 cells expressing KGF receptors. |
| Physical Appearance | White lyophilized powder. |
| Formulation | Lyophilized from a 0.2μm filtered solution in 20mM PB, pH 8.0, 1M NaCl. |
| Endotoxin | < 1EU/μg of growth factor as determined by LAL method. |
| Reconstitution | Reconstitute in sterile distilled water containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |