重组人白细胞介素-6

Interleukin-6 (IL-6) is an interleukin that in humans is encoded by the IL-6 gene and acts as both a pro-inflammatory and anti-inflammatory cytokine. It is secreted by T cells and macrophages to stimulate immune response. Furthermore, It plays an essential role in the final differentiation of B-cells into Ig-secreting cells involved in lymphocyte and monocyte differentiation. It also induces myeloma and plasmacytoma growth and induces nerve cells differentiation acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. The human IL-6 is a single non-glycosylated polypeptide chain containing 183 amino acids and it signals through a cell-surface type I cytokine receptor complex consisting of the ligand-binding IL-6Rα chain (CD126), and the signal- transducing component gp130 (also called CD130). The human IL-6 shares about 40% a.a. sequence identity with mouse and rat IL-6 and it is equally active on mouse and rat cells.

白细胞介素-6（IL-6）是一种细胞因子，由人IL-6基因编码，在体内既具有促炎作用，也具有抗炎作用。它由T细胞和巨噬细胞分泌以刺激免疫反应。此外，IL-6在B细胞最终分化为分泌免疫球蛋白的细胞过程中起关键作用，参与淋巴细胞和单核细胞的分化。IL-6还能促进骨髓瘤和浆细胞瘤的生长，并诱导神经细胞分化，对B细胞、T细胞、肝细胞、造血前体细胞及中枢神经系统细胞均有作用。人IL-6为一条非糖基化的单链多肽，由183个氨基酸组成，通过细胞表面的I型细胞因子受体复合物发挥信号作用，该复合物包括配体结合的IL-6Rα链（CD126）和信号转导组分gp130（也称为CD130）。人IL-6与小鼠和大鼠IL-6的氨基酸序列同源性约为40%，并且在人鼠细胞上均具有活性。