重组人白细胞介素-3
已报道人 IL-3 为单体形式。具体而言，人 IL-3 与小鼠 IL-3 的同源性较低，并且在人小鼠细胞上不表现活性。
Interleukin-3 (IL-3) is an interleukin, a type of biological signal (cytokine) which is encoded by the IL-3 gene located on chromosome 5 and produced primarily by activated T cells beside human thymic epithelial cells, activated murine mast cells, murine keratinocytes and neurons/astrocytes. The protein acts in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. The human IL-3 reported to be a monomer. Specifically, human and murine IL-3 share low homology and it does not show activity on murine cells
白细胞介素-3（Interleukin-3, IL-3）是一种细胞因子（cytokine），由位于染色体 5 上的 IL-3 基因编码。IL-3 主要由活化的 T 细胞产生，此外人胸腺上皮细胞、活化的小鼠肥大细胞、小鼠角质形成细胞以及神经元/星形胶质细胞也可产生该蛋白。IL-3 在造血过程中发挥作用，通过调控血液中两类相关白细胞群体——粒细胞和单核-巨噬细胞的生成、分化及功能来实现。已报道人 IL-3 为单体形式。具体而言，人 IL-3 与小鼠 IL-3 同源性较低，并且在人小鼠细胞上不表现活性。
| 目录编号 | 101-03 |
|---|---|
| 制造国家 | 美国 |
| 产品编码 | rhIL-3 |
| 规格/数量 | 10 μg, 100 μg, or 1 mg |
| 产品用途 | 本产品仅供研究使用。未经批准，不得用于人体、动物或体外诊断程序。 |
| 储存 | 收到后，请保存在 -20℃。复溶后，可在 2–8℃ 下保存长达一周。为获得最佳稳定性，建议分装后保存在 -20℃。避免反复冻融。 |
| 运输 | 凝胶包。 |
| Synonyms | Hematopoietic growth factor, MCGF, Multipotential colony-stimulating factor, P-cell-stimulating factor |
| AA Sequence | SAPMTQTTSLK TSWVNCSNMI DEIITHLKQP PLPLLDFNNL NGEDQDILME NNLRRPNLEA FNRAVKSLQN ASAIESILKN LLPCLPLATA APTRHPIHIK DGDWNEFRRK LTFYLKTLEN AQAQQTTLSL AIF |
| Source | Escherichia coli |
| Molecular Weight | 15.4 kDa, a single non-glycosylated polypeptide chain containing 134 amino acids |
| Purity | > 95% |
| Physical Appearance | White lyophilized powder. |
| Formulation | Lyophilized from a 0.2µm filtered concentrated (1mg/ml) solution in PBS, pH 7.4. |
| Endotoxin | <0.1 ng/μg of protein (<1 EU/μg) |
| Reconstitution | Reconstitute in sterile distilled water containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |