Recombinant Human Interferon-alpha2b
IFN-αs are proteins secreted by leukocyte. They are mainly involved in innate immune response against viral infection.
IFN-αs are proteins secreted by leukocyte. They are mainly involved in innate immune response against viral infection. The IFN-α family has 13 subtypes and 23 different variants. The individual proteins have molecular masses between 19-26 kDa and consist of proteins with lengths of 156-166 and 172 amino acids. All IFN-α subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino-terminal ends are variable. Many IFN-alpha subtypes differ in their sequences at only one or two positions. IFN-α2b differs from IFN-α2a by a single amino acid (the substitution of arginine for lysine at position 23), which makes up a potentially and clinically relevant difference, involving its immunogenicity.
| 目录编号 | 106-04 |
|---|---|
| 制造国家 | 美国 |
| 产品编码 | rhIFN-α2b |
| 规格/数量 | 10 μg, 100 μg, or 1 mg |
| 产品用途 | 本产品仅供研究使用。未经批准，不得用于人体、动物或体外诊断程序。 |
| 储存 | 收到后，请储存于 -20°C。复溶后，可在 2-8°C 保存最多一周。为获得最大稳定性，请分装并储存于 -20°C。避免反复冻融。 |
| 运输 | 凝胶包。 |
| Synonyms | Interferon-alpha2b, IFN-α2b |
| AA Sequence | SCDLPQTHSL GSRRTLMLLA QMRRISLFSC LKDRHDFGFP QEEFGNQFQK AETIPVLHEM IQQIFNLFST KDSSAAWDET LLDKFYTELY QQLNDLEACV IQGVGVTETP LMKEDSILAV RKYFQRITLY LKEKKYSPCA WEVVRAEIMR SFSLSTNLQE SLRSKE |
| Source | Escherichia coli |
| Molecular Weight | 19.2 kDa, a single non-glycosylated polypeptide chain containing 166 amino acids |
| Purity | > 95% |
| Physical Appearance | White lyophilized powder. |
| Formulation | Lyophilized from a 0.2µm filtered concentrated (1mg/ml) solution in PBS, pH 7.4. |
| Endotoxin | <0.1 ng/μg of protein (<1 EU/μg) |
| Reconstitution | Reconstitute in sterile distilled water containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |