重组人粒-巨噬细胞集落刺激因子

GM-CSF was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine or immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryocyte and eosinophil progenitors. On mature hematopoietic cells, GM-CSF is a survival factor for and activates the effector functions of granulocytes, monocytes/macrophages and eosinophils. GM-CSF has also been reported to have a functional role on non-hematopoietic cells. It can induce human endothelial cells to migrate and proliferate. Additionally, GM-CSF can also stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma and adenocarcinoma cell lines. GM-CSF is species specific and human GM-CSF has no biological effects on mouse cells.

GM-CSF（粒-巨噬细胞集落刺激因子）最初被描述为一种生长因子，可在体外支持粒-单核细胞前体的克隆形成。它可由多种细胞类型产生，包括活化的T细胞、B细胞、巨噬细胞、肥大细胞、内皮细胞和成纤维细胞，通常在细胞因子或免疫及炎症刺激下分泌。除了对粒-单核细胞前体具有作用外，GM-CSF 也是红系、巨核细胞和嗜酸性粒细胞前体的生长因子。在成熟造血细胞上，GM-CSF 可作为生存因子并激活粒细胞、单核/巨噬细胞和嗜酸性粒细胞的效应功能。研究还表明，GM-CSF 在非造血细胞中也具有功能作用，可诱导人内皮细胞迁移和增殖。此外，GM-CSF 还可刺激多种肿瘤细胞系的增殖，包括成骨肉瘤、癌瘤和腺癌细胞系。GM-CSF 具有物种特异性，人源 GM-CSF 对小鼠细胞没有生物学效应。