重组人酸性成纤维细胞生长因子

Acidic Fibroblast Growth Factor (aFGF) is a member of the FGF family of mitogenic peptides which is comprised of at least 23 proteins showing 35-55% amino acid sequence conservation. Unlike other FGF family members, aFGF and basic FGF (bFGF) lack signal peptides and are secreted via a different mechanism other than the classical protein secretion pathway. aFGF has been detected in large amounts in the brain. Other cells known to express aFGF include hepatocytes, vascular smooth muscle cells, CNS neurons, skeletal muscle cells, fibroblasts, keratinocytes, endothelial cells, intestinal columnar epithelium cells, pituitary basophils and acidophils. As with other FGF's, aFGF exhibits considerable species crossreactivity. aFGF and bFGF stimulate the proliferation of all cells of mesodermal origin, and many cells of neuroectodermal, ectodermal and endodermal origin.

酸性成纤维细胞生长因子（aFGF）是成纤维细胞生长因子（FGF）家族的重要成员之一。该家族包含至少23种蛋白质，氨基酸序列同源性约为35%–55%。与其他FGF家族成员不同，aFGF和碱性成纤维细胞生长因子（bFGF）不含信号肽，其分泌方式也不同于经典的蛋白分泌途径。aFGF在脑组织中含量较高。此外，多种细胞类型也可表达aFGF，包括肝细胞、血管平滑肌细胞、中枢神经系统神经元、骨骼肌细胞、成纤维细胞、角质形成细胞、内皮细胞、肠道柱状上皮细胞，以及垂体中的嗜碱性细胞和嗜酸性细胞。与其他FGF类似，aFGF具有明显的跨物种反应性。aFGF和bFGF能够促进所有来源于中胚层的细胞以及多种来源于神经外胚层、外胚层和内胚层的细胞的增殖。