Recombinant Human ErbB3 Fragment
This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures.
ErbB3 is one of four αembers of the epidermal growth factor (EGF) receptor family with no intrinsic kinase activity. Therefore, its signal transduction upon EGF ligand binding is carried by the heterodimerization of ErbB3 with a different EGF receptor kinase. ErbB3 is linked to cancer etiology and progression. Its expression can be found in keratinocytes, melanocytes, skeletal muscle cell, embryonic myoblasts and Schwann cells.
| 目录编号 | 107-11 |
|---|---|
| 制造国家 | 中国 |
| 产品编码 | rhErbB3-f |
| 规格/数量 | 5ug, 20ug, or 1mg |
| 产品用途 | 本产品仅供研究使用。未经批准，不得用于人体、动物或体外诊断程序。 |
| 储存 | 收到后，请储存于 -20°C。复溶后，可在 2-8°C 保存最多一周。为获得最大稳定性，请分装并储存于 -20°C。避免反复冻融。 |
| 运输 | 干冰。 |
| Synonyms | HER3 |
| AA Sequence | MRANDALQVL GLLFSLARGS EVGNSQAVCP GTLNGLSVTG DAENQYQTLY KLYERCEVVM GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSTLPLP NLRVVRGTQV YDGKFAIFVM LNYNTNSSHA LRQLRLTQLT EILSGGVYIE KNDKLCHMDT IDWRDIVRDR DAEIVVKDNG RSCPPCHEVC |
| Source | Escherichia coli |
| Molecular Weight | Approximately 34 KDa, a single non-glycosylated fusion protein containing the extracellular domain of human ErbB3 fragment ( 190 amino acids, Met1-Cys190 ). |
| Purity | >95% by SDS-PAGE and HPLC analyses. |
| Biological Activity | Fully biologically active as determined by the delay of spontaneous breast cancer formation in FVB/N transgenic mice and inhibit tumor development |
| Physical Appearance | A white semitransparent suspension at a concentration of 1 mg/ml. |
| Formulation | A white, semitransparent suspension, the normal content of each vial is 1 mg of protein, 1mg aluminum hydroxide and small amount of arginine, sodium chloride, sodium phosphate, and potassium phosphate |
| Endotoxin | < 1EU/μg of growth factor as determined by LAL method. |
| Reconstitution | Reconstitute in sterile phosphate-buffered saline containing 1mg aluminum hydroxide added to the vial to prepare a stock solution. |