Recombinant Human Endostatin
This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures.
Endostatin has been identified as a C-terminal fragment of Collagen type 18, a recently identified member of a family of collagen-like proteins referred to as multiplexin family. It specifically inhibits proliferation of endothelial cells although it does not affect the proliferation of EOMA cells. Endostatin also potently inhibits angiogenesis and tumor growth and has an important role in endothelial cell adhesion and cytoskeletal organization. Endostatin localizes to vessel walls (elastic fibers) and basement membranes. Recombinant Endosatin is derived from C-terminal portion of type XVIII collagen. Recombinant Endostatin causes apoptosis of HUVEC and HMVE cells.
| 目录编号 | 103-12 |
|---|---|
| 制造国家 | 中国 |
| 产品编码 | rhEndostatin |
| 规格/数量 | 20ug, 100ug, 1mg |
| 产品用途 | 本产品仅供研究使用。未经批准，不得用于人体、动物或体外诊断程序。 |
| 储存 | 收到后，请储存于 -20°C。复溶后，可在 2-8°C 保存最多一周。为获得最大稳定性，请分装并储存于 -20°C。避免反复冻融。 |
| 运输 | 干冰。 |
| Synonyms | None |
| Source | Escherichia coli |
| Molecular Weight | Approximately ~20kDa, a single glycosylated, polypeptide |
| Purity | >96% by SDS-PAGE and HPLC analyses. |
| Biological Activity | Fully biologically active. Specific activity is 50,000 units/mg, as determined by inhibition of ECE migration. |
| Physical Appearance | White lyophilized powder. |
| Formulation | Lyophilized from a 0.2μm filtered concentrated solution in PBS, pH 7.4 |
| Endotoxin | < 1EU/μg of growth factor as determined by LAL method. |
| Reconstitution | Reconstitute in sterile distilled water containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |