Recombinant Human Bone Morphogenetic Protein-7
This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures.
BMPs (Bone Morphogenetic Proteins) belong to the TGF-beta of signaling proteins and were originally identified as protein regulators of cartilage and bone formation, BMP-7 being the most potent osteoconductive factor. They have also been shown to regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. Exogenous BMP-7 promotes enhanced production of collagen type-II, aggrecan and hyaluronan. It can counteract interleukin-1 on human articular chondrocytes and is thought to maintain normal chondrocyte homeostasis. BMP-7 is synthesized as large precursor molecule which are cleaved by proteolytic enzymes. The active form can be found as homodimers or heterodimers.
| 目录编号 | 108-07 |
|---|---|
| 制造国家 | 中国 |
| 产品编码 | rhBMP-7 |
| 规格/数量 | 2ug, 10ug, 1mg |
| 产品用途 | 本产品仅供研究使用。未经批准，不得用于人体、动物或体外诊断程序。 |
| 储存 | 收到后，请储存于 -20°C。复溶后，可在 2-8°C 保存最多一周。为获得最大稳定性，请分装并储存于 -20°C。避免反复冻融。 |
| 运输 | 干冰。 |
| Synonyms | OP-1 (osteogenic protein 1) |
| AA Sequence | STGSKQRSQN RSKTPKNQEA LRMANVAENS SSDQRQACKK HELYVSFRDLGWQDWIIAPE GYAAYYCEGE CAFPLNSYMN ATNHAIVQTL VHFINPETVPKPCCAPTQLN AISVLYFDDS SNVILKKYRN MVVRACGCH |
| Source | Escherichia coli |
| Molecular Weight | Approximately 15.6 kDa, a monomeric, non-glycosylated polypeptide chain containing 139 amino acids. |
| Purity | >95% by SDS-PAGE and HPLC analyses. |
| Biological Activity | Fully biologically active. |
| Physical Appearance | White lyophilized powder. |
| Formulation | Lyophilized from a 0.2μm filtered concentrated solution in 30% acetonitrile, 0.1% TFA. |
| Endotoxin | < 1EU/μg of growth factor as determined by LAL method. |
| Reconstitution | Reconstitute in 10mM HAc to a concentration of 0.1-1.0 mg/mL. |