Recombinant Human Bone Morphogenetic Protein-4
Recombinant Human Bone Morphogenetic Protein-4 is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures.
BMPs (Bone Morphogenetic Proteins) belong to the TGF-beta of signaling proteins and were originally identified as protein regulators of cartilage and bone formation. However, they have since been shown to be involved in embryogenesis and morphogenesis of various tissues and organs. BMPs have also been shown to regulate the growth, differentiation, chemotaxis and apoptosis of various cell types, including mesenchymal cells, epithelial cells, hematopoietic cells and neuronal cells. Reduction in BMP-4 expression is associated with a number of bone- related diseases, including Fibrodysplasia Ossificans Progressiva. BMP-4 is synthesized as large precursor molecule which are cleaved by proteolytic enzymes. The active form can be found as homodimers or heterodimers.
| 目录编号 | 108-04 |
|---|---|
| 产品编码 | rhBMP-4 |
| 制造国家 | United States or China |
| 规格/数量 | 2ug, 10ug, 1mg |
| 产品用途 | 本产品仅供研究使用。未经批准，不得用于人体、动物或体外诊断程序。 |
| 储存 | 收到后，请储存于 -20°C。复溶后，可在 2-8°C 保存最多一周。为获得最大稳定性，请分装并储存于 -20°C。避免反复冻融。 |
| 运输 | 干冰。 |
| Synonyms | BMP4, ZYME, BMP2B, OFC11, BMP2B1, MCOPS6 |
| AA Sequence | SPKHHSQRAR KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCPFPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKVVLKNYQEMVV EGCGCR |
| Source | mammalian cell |
| Molecular Weight | 27.0 kDa, disulfide bond linked non-glycosylated polypeptide chains containing two 116 amino acids |
| Purity | >95% |
| Physical Appearance | White lyophilized powder. |
| Formulation | Lyophilized from a 0.2μm filtered concentrated (1mg/ml) solution in Tris-HCl at pH8.0 and 150 mM NaCl with dextran as protectant. |
| Endotoxin | <0.1 ng/μg of protein (<1 EU/μg) |
| Reconstitution | Reconstitute in sterile distilled water or 1x PBS containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |