重组人碱性成纤维细胞生长因子增强型

Basic Fibroblast Growth Factor (bFGF) is a member of the FGF family of mitogenic peptides. bFGF is extremely efficient at inducing DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. Use of native bFGF in cell biology however, is limited by the fact that bFGF rapidly degrades at physiological temperatures. ScienCell’s Recombinant Human Basic Fibroblast Growth Factor Plus is engineered for greater stability, which increases cell proliferation compare to native bFGF. The rhbFGFplus shares more than 97% amino acid identity with the 155-amino-acid human bFGF and leaves heparin and the FGF receptor binding sites unmodified.

碱性成纤维细胞生长因子（bFGF）是成纤维细胞生长因子（FGF）家族中的一种促有丝分裂多肽，能够高效诱导多种来源于中胚层和神经外胚层的细胞进行DNA合成。然而，天然bFGF在细胞生物学研究中的应用受到限制，因为其在生理温度下容易快速降解。ScienCell推出的重组人碱性成纤维细胞生长因子增强型（Recombinant Human Basic Fibroblast Growth Factor Plus）经过工程化改造，稳定性更高，能够促进细胞增殖，其效果优于天然bFGF。该重组蛋白（rhbFGFplus）与由155个氨基酸组成的人源bFGF具有超过97%的氨基酸序列同源性，并且肝素结合位点和FGF受体结合位点保持不变。