Recombinant Human Angiostatin K1-3
This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures.
Angiostatin is a proteolytic fragment of plasminogen and has been shown to act as a potent inhibitor of angiogenesis, particularly endothelial cell proliferation, and tumor growth. Angiostatin K1-3 isoform of angiostatin robustly induces the expression of E-selectin mRNA via the binding of AP1 and Ets-1 transcription factors.
| 目录编号 | 103-09 |
|---|---|
| 制造国家 | 中国 |
| 产品编码 | rhAngiostatin K1-3 |
| 规格/数量 | 10ug, 50ug, or 1mg |
| 产品用途 | 本产品仅供研究使用。未经批准，不得用于人体、动物或体外诊断程序。 |
| 储存 | 收到后，请储存于 -20°C。复溶后，可在 2-8°C 保存最多一周。为获得最大稳定性，请分装并储存于 -20°C。避免反复冻融。 |
| 运输 | 干冰。 |
| Synonyms | Angiostatin Kringles 1-3, Ang K1-3 |
| AA Sequence | VYLSECKTGN GKNYRGTMSK TKNGITCQKW SSTSPHRPRF SPATHPSEGL EENYCRNPDN DPQGPWCYTTD PEKRYDYCDI LECEEECMHC SGENYDGKIS KTMSGLECQA WDSQSPHAH GYIPSKFPNK NLKKNYCRNP DRELRPWCFT TDPNKRWELC DIPRCTTPPP SSGPTYQCLK GTGENYRGNV AVTVSGHTCQ HWSAQTPHTH NRTPENFPCK NLDENYCRNP DGKRAPWCHT TNSQVRWEYC KIPSCDSSP |
| Source | Escherichia coli |
| Molecular Weight | Approximately 30.0 kDa, a single non-glycosylated polypeptide chain containing 259 amino acids. |
| Purity | >95% by SDS-PAGE and HPLC analyses. |
| Biological Activity | Fully biologically active. The activity is assayed on anti-proliferation and anti-migration of endothelial cells in vitro and anti-angiogenesis in vivo. The specific activity of anti-migration of endothelial cells in vitro is 0.55×10^5 Units/mg. |
| Physical Appearance | White lyophilized powder. |
| Formulation | Lyophilized from a 0.2μm filtered concentrated (1.0mg/ml) solution in 20mM NaAc, pH5.5, 4% mannitol. |
| Endotoxin | < 1EU/μg of growth factor as determined by LAL method. |
| Reconstitution | Reconstitute in sterile distilled water containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |