重组人激活素 A（Activin A）
激活素 A（Activin A）属于转化生长因子-β（TGF-β）细胞因子超家族。激活素 A 可促进促卵泡激素（FSH）的合成与分泌。
Activin A belongs to the superfamily of TGF-beta cytokines. Activin A works to stimulate the synthesis and secretion of follicle-stimulating hormone (FSH) proteins. Activins are involved in many biological activities like cell proliferation, differentiation, apoptosis, immune responses, and endocrine functions. Activins are homodimers or heterodimers of two beta subunits. Activins are closely related to Inhibins in that Inhibins having one beta subunit and one alpha subunit. Human Activin A shares 100% amino acid sequence identity with bovine, mouse, and rat Activin A. Recombinant human Activin A is a homodimer of two beta A subunits, each containing 116 amino acid residues.
激活素 A（Activin A）属于转化生长因子-β（TGF-β）细胞因子超家族。激活素 A 可促进促卵泡激素（FSH）的合成与分泌。激活素参与多种生物学过程，包括细胞增殖、分化、凋亡、免疫反应以及内分泌功能。激活素由两个 β 亚基组成，可形成同源二聚体或异源二聚体。激活素与抑制素（Inhibin）关系密切，后者由一个 β 亚基和一个 α 亚基构成。人源激活素 A 与牛、小鼠和大鼠来源的激活素 A 在氨基酸序列上具有 100% 的同源性。重组人激活素 A 为由两个 βA 亚基组成的同源二聚体，每个亚基含有 116 个氨基酸残基。
| 目录编号 | 108-24 |
|---|---|
| 制造国家 | 美国 |
| 产品编码 | rhActivinA |
| 规格/数量 | 10 μg, 50 μg, 200 μg, |
| 产品用途 | 本产品仅供研究使用。未经批准，不得用于人体、动物或体外诊断程序。 |
| 储存 | 收到后请储存在 -20°C。复溶后可在 2-8°C 下保存最多一周。为确保最大稳定性，请分装并储存在 -20°C。避免反复冻融。 |
| 运输 | 凝胶包。 |
| Synonyms | Inhibin beta-A, Erythroid Differentiation Factor (EDF), follicle-stimulating hormone (FSH)-releasing protein |
| AA Sequence | GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYH ANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSP FANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMI VEECGCS |
| Source | mammalian cell |
| Molecular Weight | 26 kDa, as a disulfide-linked homodimeric protein |
| Purity | > 95% |
| Physical Appearance | Light yellow to white powder |
| Formulation | Lyophilized from a 0.2µm filtered solution in Tris-HCl, pH 8.0. |
| Endotoxin | <0.1 ng/μg of protein (<1 EU/μg) |
| Reconstitution | Reconstitute in sterile distilled water to a concentration of 0.1-0.5 mg/mL. |