CD1 小鼠脊髓星形胶质细胞
原产品编号：M1830
分离自胚胎发育第 14 天的 CD-1 小鼠脊髓组织。小鼠脊髓星形胶质细胞（MA-sc）以 P0 代冻存，并以冷冻状态运输。每瓶含有超过 5 x 105 个细胞，悬液体积为 1 mL。
Astrocytes are the major cell type in the mammalian brain. They have been implicated in a variety of supportive functions for their partner neurons in the central nervous system, such as neuronal guidance during development, ion and water homeostasis, blood flow regulation, neurotransmission, energy metabolism, and immune defense. Recent studies have shown that spinal cord astrocytes contribute to neuroinflammation by chemokine expression, which leads to the recruitment of “inflammatory” monocytes and neutrophils to the lesion site. Experimentally, spinal cord astrocytes have also been used to study the wobbler mutation and astrogliosis. As the importance of astrocyte function in the nervous system becomes more recognized, particularly in regards to the modulation of neural activity, astrocyte cultures will provide a useful tool for exploring the diverse properties and functions of these cells. MA-sc from ScienCell Research Laboratories are isolated from embryonic day 14 CD-1 mouse spinal cord.
MA-sc are cryopreserved at P0 and delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. MA-sc are characterized by immunofluorescence with antibody specific to GFAP. MA-sc are negative for mycoplasma, bacteria, yeast, and fungi. MA-sc are guaranteed to further expand for 5 population doublings under the conditions provided by ScienCell Research Laboratories.
Recommended Medium
It is recommended to use Astrocyte Medium-animal (AM-a, Cat. #1831) for culturing MA-sc in vitro.
星形胶质细胞是哺乳动物脑内的主要细胞类型，在中枢神经系统中为神经元提供多种支持功能，包括发育过程中的神经元引导、离子和水稳态调节、血流调控、神经递质传递、能量代谢及免疫防御。近期研究表明，脊髓星形胶质细胞可通过表达趋化因子参与神经炎症，促进具有炎症作用的单核细胞和中性粒细胞募集至损伤部位。在实验研究中，脊髓星形胶质细胞也被用于研究 wobbler 突变及星形胶质细胞增生。随着人们对星形胶质细胞在神经系统中功能的认识不断加深，尤其是其对神经活动的调节作用，星形胶质细胞培养物将成为研究这类细胞多样特性与功能的实用工具。ScienCell Research Laboratories 提供的 MA-sc 细胞分离自胚胎发育第 14 天的 CD-1 小鼠脊髓组织。
MA-sc 细胞以 P0 代冻存，并以冷冻状态运输。每瓶含有超过 5 x 105 个细胞，悬液体积为 1 mL。MA-sc 细胞通过使用针对胶质纤维酸性蛋白（GFAP）的特异性抗体进行免疫荧光染色鉴定。细胞经检测，不含支原体、细菌、酵母及真菌。在 ScienCell Research Laboratories 提供的培养条件下，MA-sc 细胞保证可继续扩增至少 5 个群体倍增。
推荐培养基
建议使用动物源星形胶质细胞培养基（Astrocyte Medium-animal，AM-a，产品编号：1831）进行 MA-sc 细胞的体外培养。
| 目录编号 | M1880 |
|---|---|
| 制造国家 | 美国 |
| 产品编码 | MA-sc |
| 规格/数量 | 5 x 10^5 cells/vial |
| 产品用途 | 本产品仅供研究使用。未经批准，不得用于人体、动物或体外诊断程序。 |
| 储存 | 收到后请立即将细胞从干冰中直接转移至液氮中，并在实验前始终保存在液氮中。 |
| 运输 | 干冰。 |
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