GeneQuery™ Human BMP Signaling Pathway qPCR Array Kit

The GeneQuery™ Human BMP Signaling Pathway qPCR Array Kit (GQH-BMP) meticulously profiles 88 essential genes involved in BMP (Bone Morphogenetic Protein) and BMP-related signaling pathways. BMPs are a family of growth factors known for their pivotal roles in regulating various cellular processes, including embryonic development, tissue homeostasis, and bone formation. These signaling molecules play critical roles in orchestrating cell differentiation, proliferation, and apoptosis, thereby influencing diverse physiological and pathological processes. Dysregulation of BMP signaling has been implicated in a spectrum of human diseases, ranging from developmental abnormalities to degenerative conditions. ScienCell's GeneQuery™ Human BMP Signaling Pathway qPCR Array Kit offers a comprehensive tool for examining the expression profiles of key genes involved in this pathway, facilitating the study of its regulation and potential therapeutic targets. Brief examples of how included genes may be grouped according to function are shown below:

• Receptor: TRAF6, ACVRL1, ACVR1, ACVR2A, ACVR2B, BMPR1A, BMPR2
• Cytokine: AREG, BMP1, BMP10, BMP2, BMP3, BMP4, BMP5, GDF15, IL1A
• Cell Cycle Regulation: CCNB1, CCND1, CDKN1A
• Transcription Factors: RUNX3, HIF1A, ESR1, GATA1, NFKB1, TLX2, ERBB2

GeneQuery™ qPCR array kits are qPCR-ready in a 96-well plate format, with each well containing one primer set that can specifically recognize and efficiently amplify a target gene's cDNA. The carefully designed primers ensure that: (i) the optimal annealing temperature in qPCR analysis is 65°C (with 2 mM Mg 2+ , and no DMSO); (ii) the primer set recognizes all known transcript variants of the target gene, unless otherwise indicated; and (iii) only one gene is amplified. Each primer set has been validated by qPCR with melt curve analysis, and gel electrophoresis.