Support your Differentiation, Development & Disease Model Studies
Members of the TGF-β superfamily, such as TGF-β1, TGF-β2, TGF-β3, Activin A, play diverse roles in various physiological processes including wound healing, immune regulation, cancer, inflammation, embryonic development and morphogenesis.
With robust animal-free manufacturing platform and rigorous quality control procedures, ScienCell provides high-quality TGF-β superfamily growth factors that are:
- Animal origin-free (AOF) and carrier protein-free
- Highly pure (>95%, by SDS-PAGE, minimal interference from contaminants)
- Highly bioactive (equally or more bioactive than other dominant suppliers)
- Highly reproducible with excellent lot-to-lot consistency
Shared among these members are dimeric structures and receptor complexes composed of both type I and type II receptor subunits, each containing serine/threonine kinase domains. Upon ligand binding, the type II receptor phosphorylates and activates the type I receptor, initiating a signaling cascade reliant on Smad proteins that ultimately regulates gene expression. This superfamily of proteins plays diverse roles in adult stem cell differentiation, cell proliferation, survival, apoptosis, and tissue remodeling.
