Recombinant Human Interleukin-1 beta

Recombinant Human Interleukin-1 beta (rhIL-1b) is a secreted pro-inflammatory cytokine belonging to the IL-1 family, produced primarily by activated monocytes, macrophages, and dendritic cells. The human IL-1b precursor (pro-IL-1b, 269 amino acids) is synthesized as an inactive cytoplasmic protein that undergoes proteolytic cleavage by caspase-1 (IL-1b–converting enzyme) to yield the mature 17 kDa cytokine.